abstract：:Long-term results of different studies employing cisplatin-based chemotherapy in advanced ovara in cancer are just beginning to be published. Available data suggest that the rate of relapse decreases but does not cease, and the question of whether cisplatin-based chemotherapy results in an improved cure in advanced ov...

journal_title：Anticancer research

authors： De Pree N,Wils J

更新日期：1989-11-01 00:00:00

abstract：:The most active fraction (Fr. VI) of antitumor and antiviral pine cone extract was subjected to chemical structure analysis. IR, UV, and ESR spectroscopies, in addition to chromatographic analysis on cellulose-TLC plates, reveal that the major component of Fr. VI includes structures belonging to the lignin family. A c...

journal_title：Anticancer research

authors： Sakagami H,Oh-Hara T,Kaiya T,Kawazoe Y,Nonoyama M,Konno K

更新日期：1989-11-01 00:00:00

abstract：:A clearly benign parotid tumor, an adenolymphoma, was studied cytogenetically using short-term cultured material. The first preparation showed only a normal stemline. The two subsequent preparations were both characterized by a pseudodiploid stemline with the karyotype 46,XY,del(7) (p12p14-15), t(11;19) (q21;p12-13). ...

journal_title：Anticancer research

authors： Mark J,Dahlenfors R,Stenman G,Nordquist A

更新日期：1989-11-01 00:00:00

abstract：:The effect of retinoid induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on sialyltransferase activity and sialic acid content was investigated. Inhibition by retinol acetate of cell invasive potential was accompanied by a significant decrease in the enzyme activity of intact cells as...

journal_title：Anticancer research

authors： Ledinko N,Fazely F

更新日期：1989-11-01 00:00:00

abstract：:This work includes results from studies on oesophageal cytopathology, dietary studies and the correlation of oesophageal cytological abnormalities and micronutrient blood levels in populations at risk for oesophageal carcinoma (OC) in remote rural areas of Southern Africa. The incidence of malignant lesions was 1.6 - ...

journal_title：Anticancer research

authors： Jaskiewicz K

更新日期：1989-11-01 00:00:00

abstract：:An examination of eighteen thiols and thio ethers revealed that the simultaneous administration of several of these with cis-platinum (CDDP) at 7.5 mg/kg (25 mumols/kg) iv, as a single injection to rats bearing the Walker 256 carcinosarcoma led to significant reduction in the nephrotoxicity typically found with cis-pl...

journal_title：Anticancer research

authors： Jones MM,Basinger MA

更新日期：1989-11-01 00:00:00

abstract：:Although several chemical carcinogenes have been shown to induce malignant transformation in human cells in culture, the molecular events involved in conversion of normal cells to malignant cells remain unknown at present. Normal human cells seem to be resistant to transformation by a single oncogene unless these cell...

journal_title：Anticancer research

authors： Khoobyarian N,Marczynska B

更新日期：1989-09-01 00:00:00

abstract：:Several lines of evidence have recently been presented indicating that proteins previously referred to as Mr 62,000-67,000 transformation-associated secreted phosphoprotein, 2ar, osteopontin, bone sialoprotein I, and 44K Dal bone phosphoprotein are all very likely encoded by the same gene. We have found that markedly ...

journal_title：Anticancer research

authors： Senger DR,Perruzzi CA,Papadopoulos A

更新日期：1989-09-01 00:00:00

abstract：:Complementary antitumor treatments are required to increase the cure rate achieved by surgery and/or radiotherapy by avoiding future recurrences and metastases. The growth of most solid tumors, particularly carcinomas, depends upon the simultaneous development of internal tumor vasculature to allow the proliferation o...

journal_title：Anticancer research

authors： Madarnas P,Benrezzak O,Nigam VN

更新日期：1989-07-01 00:00:00

abstract：:The effect of treatment schedule on the antitumor activity of a new platinum derivative, glycolate-0,0'-diammineplatinum (II) (254S) compared with cis- diamminedichloroplatinum (II) (CDDP) was investigated using ascites L1210 leukemia and solid Lewis lung carcinoma. The drugs were given i.p. by three treatments: as a ...

journal_title：Anticancer research

authors： Suzumura Y,Kato T,Ueda R,Ota K

更新日期：1989-07-01 00:00:00

abstract：:Treatment of C57BL/6 mice bearing Lewis lung carcinoma or of BALB/c mice bearing EMT6 sarcoma with tumor necrosis factor (TNF), lipopolysaccharides (LPS) or interferon caused necrosis of the solid tumors and regression. Toxicity was observed in tumor-bearing animals when TNF or LPS were used at effective antitumoral d...

journal_title：Anticancer research

authors： Chokri M,Freudenberg M,Galanos C,Poindron P,Bartholeyns J

更新日期：1989-07-01 00:00:00

abstract：:The published literature describing the spectrum of resistance and cross-resistance to cytotoxic agents by human and murine tumour cell lines maintained in long-term culture is reviewed. The data available demonstrate that for many cytotoxic agents, especially those of higher molecular weight, cross-resistance is prop...

journal_title：Anticancer research

authors： Mattern J,Edler L,Volm M

更新日期：1989-07-01 00:00:00

abstract：:A new treatment is proposed for mice bearing a Krebs ascitic tumor targeting on both the malignant cells and the host cells having the "cancer functioning" (cancer cells) (Anticancer Res 9: 941-946 1989). It is shown that the treatment (a) injure specifically via 64Cu transmutation the DNA of the malignant cells and f...

journal_title：Anticancer research

authors： Guillé E,Apelgot S

更新日期：1989-07-01 00:00:00

abstract：:An in vitro pilot study was conducted of the possible utility of combining low doses of cytosine arabinoside (araC) and GM-CSF to stimulate leukemic cell differentiation. Cytosine arabinoside induced macrophage differentiation in some cultures but only when the drug produced substantial cytostatic effects. GM-CSF, whe...

journal_title：Anticancer research

authors： Gao XZ,Yin MY,Preisler HD

更新日期：1989-07-01 00:00:00

abstract：:Monoclonal antibodies TP-1 and TP-3, which detect an antigen expressed on the cells of human osteosarcoma, were tested by immunohistochemical staining for binding to normal and neoplastic canine tissues. In dogs, as in man, TP antibodies stained the tumor cells of all (13/13) osteosarcomas tested. Limited staining was...

journal_title：Anticancer research

authors： Haines DM,Bruland OS

更新日期：1989-07-01 00:00:00

abstract：:Over 600 analogues of mitomycin C (MMC) have been made in the past and more recently a number of Mitomycin A (MMA) derivatives have been prepared. Since many of the MMA type had the same organic side chain at the 7-position as previously prepared MMC analogues it was of interest to see if the biological effects of MMC...

journal_title：Anticancer research

authors： Bradner WT,Remers WA,Vyas DM

更新日期：1989-07-01 00:00:00

abstract：:The Feulgen-DNA content of squamous carcinoma cell nuclei from the human esophagus was assessed in punch biopsies from 47 untreated patients. Forty-four of the 47 biopsies (93.6%) demonstrated aneuploid cell populations, and the remaining 3 (6.4%) were non-diploid. Previous studies have demonstrated that in esophageal...

journal_title：Anticancer research

authors： Munck-Wikland E,Auer G,Kuylenstierna R,Lindholm J,Rubio C

更新日期：1989-05-01 00:00:00

abstract：:In order to improve the knowledge of prolactin receptors (PRL-R) in human breast tumors, we studied PRL-R modulation by lactogenic and steroid hormones in the PRL-R rich human breast cancer cell-line, T-47 D. The PRL-R were assayed on a preparation of cell total membranes. We demonstrated an abnormal homologous in vit...

journal_title：Anticancer research

authors： Leroy-Martin B,Peyrat JP

更新日期：1989-05-01 00:00:00

abstract：:Flow cytometric DNA analysis was performed in 67 tubular, tubulovilous and villous rectal adenomas with different degree of dysplasia. One of the adenomas contained a focus of early invasive carcinoma. All but one of the 67 adenomas had near diploid DNA histograms; the exception was a tubular adenoma with severe dyspl...

journal_title：Anticancer research

authors： Enblad P,Glimelius B

更新日期：1989-05-01 00:00:00

abstract：:K18 is a conjugate of human immunoglobulin G and melphalan and has been reported to accumulate selectively in the tumor. In the present study, the in vitro antitumor effect of K18 was assessed in a total of 107 fresh human tumors by DNA synthesis (3H-thymidine incorporation) inhibition assay, and compared with that of...

journal_title：Anticancer research

authors： Shiraishi T,Nio Y,Imai S,Ohgaki K,Tobe T

更新日期：1989-05-01 00:00:00

abstract：:The use of lysozyme preparations in the treatment of tumor diseases is based on more than 30 years' experience, using different methodologies and showing various results from which suggestions on the mechanism of action were derived. Lysozymes have no established place in the treatment of human tumors in spite of some...

journal_title：Anticancer research

authors： Sava G,Benetti A,Ceschia V,Pacor S

更新日期：1989-05-01 00:00:00

abstract：:The specificities and surface markers of murine autocytotoxic cells induced by in vitro culture with interleukin 2 (IL2) were studied. Culturing murine spleen cells with recombinant human IL2 resulted in the generation of cytotoxic cells which killed syngeneic lymphoblasts and syngeneic activated macrophages (M phi). ...

journal_title：Anticancer research

authors： Suzuki H,Ikemoto M,Kamitani T,Hoshino K,Yano S

更新日期：1989-03-01 00:00:00

abstract：:The poor response of pancreatic adenocarcinoma to conventional chemotherapy has prompted us to search for innovative treatment approaches. Verapamil, a calcium channel blocker, has been reported to increase the doxorubicin sensitivity of several tumor models with acquired resistance, often in association with decrease...

journal_title：Anticancer research

authors： Chang BK,Brenner DE,Gutman R

更新日期：1989-03-01 00:00:00

abstract：:Chemosensivity testing in 11 retinoblastoma (RB) cell lines identified five tumors showing cross-resistance to plant alkaloids, alkylating agents, anthracycline antibiotics, and antimetabolites, suggestive of the multidrug-resistant (MDR) phenotype described in other tumors. Only two tumors had been clinically exposed...

journal_title：Anticancer research

authors： Chan HS,Canton MD,Gallie BL

更新日期：1989-03-01 00:00:00

abstract：:A human ovarian mesodermal mixed heterologous carcinoma, with a high content of cellular retinol-binding protein (CRBP), was used to study the effects of retinoid and hormonal treatment on tumour CRBP content, tumour growth rate, differentiation and turnover of CRBP. Tumour growth in general was accompanied by an incr...

journal_title：Anticancer research

authors： Wahlberg P,Fex G,Wennerberg J,Willén R

更新日期：1989-01-01 00:00:00

abstract：:Tumor cell invasion was studied using the 9-day chick embryo skin (CES). The invasion process was broken down into 4 sequential events: adhesion, penetration, proliferation and colonization. Tumor cells used in this study included cells from various human and canine solid tumors, tumor cell lines from human and animal...

journal_title：Anticancer research

authors： Katoh A,Charoensiri S

更新日期：1989-01-01 00:00:00

abstract：:In a previous study we determined that the fine needle aspiration (FNA) biopsy of thyroid produces 16% of false-negative cases (FNC). In order to determine the value of quantitative cytology (QC) as a tool for predicting the FNC result, thirty-seven cases, 18 of which were operated (histologically benign: 13; malignan...

journal_title：Anticancer research

authors： Liautaud-Roger F,Dufer J,Pluot M,Delisle MJ,Coninx P

更新日期：1989-01-01 00:00:00

abstract：:The accumulation of vincristine in leukemic cells and normal mononuclear cells and the effect of verapamil on cellular drug accumulation were studied. Leukemic cells were isolated from 10 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia. Normal mononuclear cells were collected from ...

journal_title：Anticancer research

authors： Gruber A,Reizenstein P,Peterson C

更新日期：1989-01-01 00:00:00

abstract：:Treatment of advanced prostatic cancer is currently based on hormonal manipulation. In 1982 Labrié supported a new concept of hormonal treatment based on complete androgen blockade. The objective of this study was to evaluate the effects of total androgen suppression, achieved by the combination of a LHRH agonist (bus...

journal_title：Anticancer research

authors： Neri B,Bartalucci S,Pieri A,Gemelli MT,Rizzo M,Bartoletti R,Trippitelli A,Paoletti MC

更新日期：1989-01-01 00:00:00

abstract：:Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. Some 131 human cancer-specific chromosomal structural rearrang...

journal_title：Anticancer research

authors： De Braekeleer M

更新日期：1988-11-01 00:00:00

abstract：:Dynamic liver RES scintigraphy with Nanocoll (99Tcm albumin colloid - 50 nm diameter) assessing RES-macrophage phagocytic function was performed in 40 control, 73 RES-stimulated non-tumour-bearing and 59 tumour-bearing Wistar/FU rats in vivo. Tumour-bearing rats were inoculated with 10(6) x 1.0 cells of a syngeneic ni...

journal_title：Anticancer research

authors： Holmberg SB,Hafström L,Jacobsson L

更新日期：1988-11-01 00:00:00

abstract：:Phorbol ester, 12-0-Tetradecanoyl-13-Phorbol-Acetate (TPA), induces a terminal macrophage-like differentiation of cells from human acute myelogenous leukemia cell lines. We report here that blastoid cells obtained from acute nonlymphocytic leukemia (M1-M2) undergo differentiation-related changes characteristic of macr...

journal_title：Anticancer research

authors： Joshi KS,Rao SG,Joshi DS,Advani SH,Bhisey AN

更新日期：1988-11-01 00:00:00

abstract：:In procaryotic and also in eucaryotic cells, several systems for repairing the DNA damage have been discovered. The mechanism and genetic control of DNA excision-repair and SOS have been extensively studied. These repair processes help prevent lesions from interfering with DNA functions or from converting into permane...

journal_title：Anticancer research

authors： Tonini GP

更新日期：1988-09-01 00:00:00

abstract：:The binding and tissue distribution of 125I-labeled rabbit anti-sarcoma 180 (S-180) immunoglobulin G (IgG) (RAS-180G), normal rabbit IgG (NRG) and ICR mouse IgGs from normal (NMG) and S-180-bearing ICR mice (AS-180G) were studied in ICR mice bearing S-180. 125I-labelled IgGs preparted from normal (NC57G) or Adenocarco...

journal_title：Anticancer research

authors： Niimura K,Furusho T,Fujii M,Oguchi Y,Fujii T,Takahashi N,Matsunaga K,Sugita N,Yoshikumi C,Kawai Y

更新日期：1988-07-01 00:00:00

abstract：:Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one...

journal_title：Anticancer research

authors： Hill M,Hillova J,Mariage-Samson R,Brada Z

更新日期：1988-07-01 00:00:00

abstract：:The model of human malignant tumors, heterotransplanted and passaged into athymic nude mice, proved to be a valuable tool for nutritional oncology. It showed that several human tumors proliferate in distinct dependence on the available vitamin B6. A surplus of the vitamin causes enhancement of growth. Proliferation is...

journal_title：Anticancer research

authors： Fortmeyer HP,Timm C,Blum U,Wenisch HJ,Förster H

更新日期：1988-07-01 00:00:00

abstract：:AD 198, a novel lipophilic N-alkyl derivative of adriamycin (ADR) and a potential anticancer agent for preclinical development, was studied for its effects on the activities of DNA and RNA polymerases in vitro and its ability to bind DNA. AD 198, which contains a benzyl substituent on the glycosidic amine, was found t...

journal_title：Anticancer research

authors： Lameh J,Chuang LF,Israel M,Chuang RY

更新日期：1988-07-01 00:00:00

abstract：:Bone-seeking radionuclides have been used to treat bone pain due to metastatic bone disease for over 40 years. More than 10 clinical studies using radiostrontium (Sr-89) have shown benefit in about 70-80% of patients having refractory bone pain from prostate, breast and other metastatic bone cancers, with minimal hema...

journal_title：Anticancer research

authors： Kim SI,Chen DC,Muggia FM

更新日期：1988-07-01 00:00:00

abstract：:The structural specificities of the natural polyamines putrescine (Put), spermidine (Spd) and spermine (Spm) for cell growth are rather stringent, suggesting that appropriate structural analogues of these polycations could serve as potential antineoplastic agents via polyamine antagonism. Norspermidine (Nspd), a homol...

journal_title：Anticancer research

authors： Prakash NJ,Bowlin TL,Davis GF,Sunkara PS,Sjoerdsma A

更新日期：1988-07-01 00:00:00

abstract：:The effects induced by a low dose cyclophosphamide treatment (CPA) along with an attempt of estradiol-17-beta (E2) cell recruitment, on the bioenergetics and the phosphomonoesters/phosphodiesters (PME/PDE) ratio in the transplantable MXT mouse mammary tumor have been studied by 31P-NMR spectroscopy in vivo. Our result...

journal_title：Anticancer research

authors： Scheiber C,Kiss R,De Launoit Y,Frühling J

更新日期：1988-05-01 00:00:00